Treated Hypertension has No Influence on the Efficacy of Alendronate in the Therapy of Postmenopausal Osteoporosis: A Non-Randomized, Non-Blind, Controlled Prospective Study
RESEARCH ARTICLE

Treated Hypertension has No Influence on the Efficacy of Alendronate in the Therapy of Postmenopausal Osteoporosis: A Non-Randomized, Non-Blind, Controlled Prospective Study

Doerte Matziolis, * Open Modal , 1 Monika Drewke2 Georg Matziolis1 Carsten Perka1
Authors Info & Affiliations
The Open Orthopaedics Journal • 07 Jan 2011 • RESEARCH ARTICLE • DOI: 10.2174/1874325001105010027

Abstract

Changes in hormone metabolism during menopause are involved in the development of osteoporosis and arterial hypertension. A mutual influence of these two clinical pictures is evident on the basis of pathophysiological factors.

In this study, we investigated whether a drug therapy of hypertension influences the efficacy of a bisphosphonate (alendronate) in the treatment of postmenopausal osteoporosis. For this purpose, 60 female patients were enrolled in the study, 30 of them on drug treatment for hypertension in addition to requiring treatment for osteoporosis, while the control group was only suffering from osteoporosis.

Bone density was measured at the start of the study and 6 months after therapy (QCT).

A significant increase in bone density was demonstrated in both groups, while a difference between the groups could not be seen.

Treated arterial hypertension does not have a negative influence on the treatment of postmenopausal osteoporosis with alendronate. Rather, the concomitant treatment of these two clinical pictures would appear to make sense, in order to reduce morbidity and mortality.

Keywords: Osteoporosis, hypertension, alendronate, bisphosphonate.