RESEARCH ARTICLE


Perioperative D-Dimer Levels in Patients with Musculoskeletal Tumors



Takeshi Morii*, Kazuo Mochizuki, Masazumi Kotera, Naoaki Imakiire, Takahiro Moriwaki, Kazuhiko Satomi
Department of Orthopaedic Surgery, Kyorin University School of Medicine, 6-20-2 Shinkawa Mitaka, Tokyo 181-8611, Japan


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Creative Commons License
© Morii et al.; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the Department of Orthopaedic Surgery, Kyorin University, 6-20-2 Shinkawa Mitaka, Tokyo 181-8611, Japan; Tel: +81-422-47-5511; Fax: +81-422-48-4206; E-mail: t-morii@gb3.so-net.ne.jp or t-morii@kyorin-u.ac.jp


Abstract

Background:

D-dimer (DD) levels have been reported as a sensitive but non-specific indicator for deep vein thrombosis (DVT) and pulmonary embolism (PE). Few reports have examined perioperative DD levels in musculoskeletal tumor.

Materials/Methods:

Subjects comprised 77 patients who had undergone oncological resection of musculoskeletal tumor. DD levels were assessed preoperatively and on postoperative days 1 and 7. Multidetector-row computed tomography (MD-CT) was performed to detect DVT/PE for cases with DD level >10.0 µg/ml.

Results:

Mean preoperative DD level was 0.84 µg/ml. Significant elevation of postoperative DD levels was confirmed. DD levels were significantly changed by various clinical conditions, such as malignancy, age and prosthetic reconstruction. In 4 of 5 cases with postoperative DD levels >10.0 µg/ml, DVT/PE was detected.

Conclusion:

Activation of the coagulation system by surgery and heterogeneity of DD levels under various clinical conditions in musculoskeletal tumor patients were suggested.