Perioperative D-Dimer Levels in Patients with Musculoskeletal Tumors
Takeshi Morii*, Kazuo Mochizuki, Masazumi Kotera, Naoaki Imakiire, Takahiro Moriwaki, Kazuhiko Satomi
Identifiers and Pagination:Year: 2008
First Page: 130
Last Page: 132
Publisher Id: TOORTHJ-2-130
Article History:Received Date: 3/6/2008
Revision Received Date: 4/7/2008
Acceptance Date: 1/8/2008
Electronic publication date: 26/8/2008
Collection year: 2008
open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
D-dimer (DD) levels have been reported as a sensitive but non-specific indicator for deep vein thrombosis (DVT) and pulmonary embolism (PE). Few reports have examined perioperative DD levels in musculoskeletal tumor.
Subjects comprised 77 patients who had undergone oncological resection of musculoskeletal tumor. DD levels were assessed preoperatively and on postoperative days 1 and 7. Multidetector-row computed tomography (MD-CT) was performed to detect DVT/PE for cases with DD level >10.0 µg/ml.
Mean preoperative DD level was 0.84 µg/ml. Significant elevation of postoperative DD levels was confirmed. DD levels were significantly changed by various clinical conditions, such as malignancy, age and prosthetic reconstruction. In 4 of 5 cases with postoperative DD levels >10.0 µg/ml, DVT/PE was detected.
Activation of the coagulation system by surgery and heterogeneity of DD levels under various clinical conditions in musculoskeletal tumor patients were suggested.