Perioperative D-Dimer Levels in Patients with Musculoskeletal Tumors

Takeshi Morii*, Kazuo Mochizuki, Masazumi Kotera, Naoaki Imakiire, Takahiro Moriwaki, Kazuhiko Satomi
Department of Orthopaedic Surgery, Kyorin University School of Medicine, 6-20-2 Shinkawa Mitaka, Tokyo 181-8611, Japan

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© Morii et al.; Licensee Bentham Open.

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* Address correspondence to this author at the Department of Orthopaedic Surgery, Kyorin University, 6-20-2 Shinkawa Mitaka, Tokyo 181-8611, Japan; Tel: +81-422-47-5511; Fax: +81-422-48-4206; E-mail: or



D-dimer (DD) levels have been reported as a sensitive but non-specific indicator for deep vein thrombosis (DVT) and pulmonary embolism (PE). Few reports have examined perioperative DD levels in musculoskeletal tumor.


Subjects comprised 77 patients who had undergone oncological resection of musculoskeletal tumor. DD levels were assessed preoperatively and on postoperative days 1 and 7. Multidetector-row computed tomography (MD-CT) was performed to detect DVT/PE for cases with DD level >10.0 µg/ml.


Mean preoperative DD level was 0.84 µg/ml. Significant elevation of postoperative DD levels was confirmed. DD levels were significantly changed by various clinical conditions, such as malignancy, age and prosthetic reconstruction. In 4 of 5 cases with postoperative DD levels >10.0 µg/ml, DVT/PE was detected.


Activation of the coagulation system by surgery and heterogeneity of DD levels under various clinical conditions in musculoskeletal tumor patients were suggested.