Clinical Significance of Additional Wide Resection for Unplanned Resection of High Grade Soft Tissue Sarcoma
T Morii*, H Yabe, H Morioka, U Anazawa, Y Suzuki, Y Toyama
Identifiers and Pagination:Year: 2008
First Page: 126
Last Page: 129
Publisher ID: TOORTHJ-2-126
Article History:Received Date: 9/5/2008
Revision Received Date: 4/6/2008
Acceptance Date: 29/6/2008
Electronic publication date: 30/7/2008
Collection year: 2008
open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/), which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited.
Unplanned resection of musculoskeletal sarcoma involves tumor excision without any suspicion of malignancy or regard for the necessity of defining adequate margins. For orthopaedic oncologists, many opportunities arise for management of unplanned resections initially performed by non-specialist surgeons. The puropose of this study is to assess the clinical outcomes and the problems of the patients with unplanned resection of high-grade soft tissue sarcoma.
77 consecutive patients were retrospectively reviewed. Oncological outcomes together with validity and problems of additional treatments were analyzed.
Five-year local recurrence-free survival, metastasis-free survival, event-free survival and total survival were 71.55%, 73.2%, 57.5% and 85.9%, respectively. Among adjuvant therapy including additional wide resection, radiotherapy and systemic chemotherapy, only additional wide resection significantly improved oncological outcomes.
Additional wide resection appears to be effective in the treatment of high-grade soft tissue sarcomas following primary resection with compromised margins of resection.