A Systematic Review and Meta-Analysis of En-Bloc vs Intralesional Resection for Giant Cell Tumor of Bone of the Distal Radius

Theresa J.C Pazionis 1, Hussain Alradwan 1, 5, Benjamin M Deheshi 1, 2, Robert Turcotte 3, Forough Farrokhyar4, Michelle Ghert*, 1, 2
1 McMaster University Department of Orthopaedic Surgery, Hamilton ON, Canada
2 Juravinski Cancer Centre, Hamilton ON, Canada
3 McGill University, Montreal QC, Canada
4 McMaster University Department of Surgery, Hamilton ON, Canada
5 The Saudi Ministry of Higher Education, Riyadh, Saudi Arabia

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© Pazionis et al.; Licensee Bentham Open.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution License ( which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited.

* Address correspondence to this author at the 699 Concession Street, Level 3 Surgical Oncology, Hamilton, ON, L8V5C2, Canada; Tel: 1-905-389-9495, Ext. 64089; Fax: 905-575-6343; E-mail:



Surgical management of Giant Cell Tumor of Bone of the distal radius (GCTDR) remains controversial due to risk of local recurrence (LR) offset by functional limitations which result from en-bloc resection. This study aims to determine the oncologic and functional outcomes of wide excision (WE) vs intralesional curettage (IC) of GCTDR.


A complete search of the applicable literature was done. Included studies reported on patients from the same cohort who were surgically treated for GCTDR with WE or IC. Two reviewers independently assessed all papers. The primary outcome measure was LR.


One-hundred-forty-one patients from six studies were included: 60 treated with WE, and 81 with IC. Five WE patients (8%) suffered LR whereas 25 IC patients (31%) did. The odds of LR were three times less in the WE group vs the IC group. MSTS1993 scores, where available, were on average 'good' with WE and 'excellent' with IC.


Within statistical limitations the data support an attempt, where feasible, at wrist joint preservation and superior function with IC. Intralesional curettage is reasonable when the functional benefit outweighs the risk of recurrence as is the case in many cases of GCT of the distal radius.

Keywords: Curettage, excision, giant cell tumor, meta-analysis, radius, surgery.