RESEARCH ARTICLE


Relationship Between Mechanical Properties and Bone Mineral Density of Human Femoral Bone Retrieved from Patients with Osteoarthritis



Yvonne Haba, Tobias Lindner, Andreas Fritsche, Ann-Kristin Schiebenhöfer, Robert Souffrant, Daniel Kluess, Ralf Skripitz, Wolfram Mittelmeier, Rainer Bader*
Department of Orthopaedics, Biomechanics and Implant Technology Research Laboratory, University Medicine Rostock, Germany


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© Haba et al.; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the Department of Orthopaedics, Doberaner Str. 142, D-18057 Rostock, Germany; Tel: +49(0)381 494-9337; Fax: +49(0)381 494-9308; E-mail: rainer.bader@med.uni-rostock.de


Abstract

The objective of this study was to analyse retrieved human femoral bone samples using three different test methods, to elucidate the relationship between bone mineral density and mechanical properties. Human femoral heads were retrieved from 22 donors undergoing primary total hip replacement due to hip osteoarthritis and stored for a maximum of 24 hours postoperatively at + 6 °C to 8 °C.

Analysis revealed an average structural modulus of 232±130 N/mm2 and ultimate compression strength of 6.1±3.3 N/mm2 with high standard deviations. Bone mineral densities of 385±133 mg/cm2 and 353±172 mg/cm3 were measured using thedual energy X-ray absorptiometry (DXA) and quantitative computed tomography (QCT), respectively. Ashing resulted in a bone mineral density of 323±97 mg/cm3. In particular, significant linear correlations were found between DXA and ashing with r = 0.89 (p < 0.01, n = 22) and between structural modulus and ashing with r = 0.76 (p < 0.01, n = 22).

Thus, we demonstrated a significant relationship between mechanical properties and bone density. The correlations found can help to determine the mechanical load capacity of individual patients undergoing surgical treatments by means of noninvasive bone density measurements.

Keywords:: Human trabecular bone, femoral head, bone mineral density, mechanical properties.