Computer-Assisted Navigation in High Tibial Osteotomy: A Systematic Review of the Literature

Natasha E Picardo*, 1, Wasim Khan 2, David Johnstone 3
1 Bone Tumour Unit, Royal National Orthopaedic Hospital, Stanmore, Middlesex, HA7 4LP, UK
2 University College London Institute of Orthopaedics and Musculoskeletal Sciences, Royal National Orthopaedic Hospital, Stanmore, Middlesex, HA7 4LP, UK
3 Stoke Manderville Hospital, Aylesbury, Buckinghamshire, HP21 8AL, UK

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© Picardo et al.; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the Bone Tumour Unit, Royal National Orthopaedic Hospital, Stanmore, Middlesex, HA7 4LP, UK; Tel: 0208 909 5532; Fax: 0208 909 5100; E-mail:


High tibial osteotomy (HTO) is a procedure which aims to change the mechanical axis of the lower limb, transferring the body weight across healthy articular cartilage. Several studies have shown that accurate correction is the leading predictor for success.

In this article, we systematically review the computer-assisted techniques that have been used in attempts to increase the accuracy of the surgery and improve postoperative outcomes. The results of the cadaveric and clinical studies to date are presented and the benefits and pitfalls of navigation are discussed.

Keywords: Computer-assisted surgery, high tibial osteotomy, kinematic navigation system, knee, mechanical axis, medial gonarthrosis, navigation, varus deformity.


High tibial osteotomy (HTO) was first introduced in 1958 by Jackson [1]. It is a well-known treatment option for unicompartmental osteoarthritis of the knee with varus malalignment, particularly in young, active patients (less than 65 years of age with moderate arthritis), where total knee replacement is not advisable [2-4]. HTO is a realignment procedure which redistributes weight-bearing load from the diseased medial compartment to the relatively unaffected lateral compartment of the knee. This can alleviate symptoms and slow disease progression, thereby deferring subsequent total knee arthroplasty. Furthermore fibrocartilaginous proliferation is seen to occur in the diseased compartment, providing some evidence of biologic healing [5].

Popular techniques include medial opening wedge HTO with or without interposition of bone graft, lateral closed wedge technique and dome osteotomy. Many surgeons prefer the medial opening wedge technique as it is less invasive, involving a single transverse osteotomy and thereby avoiding damage to the lateral part of the knee, including the fibula and common peroneal nerve [6, 7]. There is no loss of osseous substance and it allows adjustment to be made in the sagittal and coronal planes [3].

Many fixation techniques have been described including external fixation with progressive distraction and a variety of internal fixation devices [8, 9]. Proximal tibial osteotomies are regarded as technically demanding procedures with a steep learning curve. They provide the best results when they are well indicated and when the lower limb is accurately aligned.

The Ideal Alignment

Different recommendations are found in the literature, regarding the amount of correction that should be achieved postoperatively and no clear guidelines exist [10]. Most studies have found that slight overcorrection of valgus is essential to achieve longevity and avoid varus deformity recurrence [11]. Some authors refer to the anatomical axis of the tibia and femur and recommend a postoperative alignment of 8-10° valgus [12-14]. Other authors concentrate on the mechanical alignment and recommend that this should be moved to 3-6° of mechanical valgus, noting that results deteriorate outside this range [3, 15]. When the mechanical axis passes through the centre of the knee, the medial compartment bears 67% of the load during single leg stance and when the mechanical axis is moved to 6° of valgus, the load is 40% medial and 60% lateral [16]. Overcorrection to valgus is therefore necessary to unload the medial compartment.

In 1979, Fujisawa et al. [2] published results of a retrospective arthroscopic analysis of 54 patients performed after closing wedge HTO. The medial and lateral edges of the medial and lateral plateaus were considered to be 100% and the centre of the knee was 0%. Best results were achieved when the mechanical axis passed through the lateral 30-40% of the tibial plateau as measured from its midpoint. This region has become known as the Fujisawa point. This area corresponds roughly to recommendations by Miniaci [17] and Noyes [18] who recommended that the weightbearing line should pass through a point at 60-70% of the tibial plateau width, as measured from the medial cortex. Years later, Jakob and Murphy modified the Fujisawa point, based on the degree of medial articular damage [19]. If the medial compartment degeneration is minimal, the goal is correction through the medial third (one third of the distance to Fujisawa’s point). With severe arthrosis of the medial compartment, the mechanical axis is shifted to pass through Fujisawa’s point.

Problems with Conventional HTO

In the long-term, the outcomes of HTO strongly depend on the achievement of desired correction, yet conventional HTO techniques have demonstrated high variability [3]. It is accepted that approximately 20% of patients will not have optimal limb axis correction as measured by postoperative radiographs [20]. This can be due to imprecise preoperative planning, inaccurate wedge cuts or poor control of intraoperative alignment [21, 22]. Another cause may be unstable fixation of the osteotomy during the bone healing process leading to secondary correction loss with revarisation or valgus overcorrection [23].

Traditional methods to assess the intraoperative mechanical axis have been crude and unreliable and this is the most common cause of over or undercorrection [10]. The cable method is most commonly used, which utilises fluoroscopy and creates a straight radio-opaque line between the centres of the hip and ankle joints to allow interpolation as to where the axis crosses the knee [24]. Other methods include using a grid with radio-opaque reference lines or the measurement of correction angles on radiographs intraoperatively [16, 25]. These techniques have high intraobserver variation and low reproducibility and allow only momentary evaluation [26]. It is difficult to obtain long leg views intraoperatively and accuracy can also be affected by limb rotation, alignment guide position and the quality of the image intensification image [27].

Undercorrection of the frontal plane deformity leads to progression of medial joint arthritis and patient dissatisfaction [23]. Overcorrection can lead to patellar subluxation, patella baja, medial joint line opening and rapid degeneration of the lateral cartilage [28]. Another issue is that multiplanar deformity may be present and many conventional techniques fail to control for this.

Inadvertent sagittal plane realignment is a common problem after conventional open wedge HTO. An increase in the tibial slope occurs as the proximal tibia has a 3 dimensional structure with a triangular shape [10]. Noyes et al. [29] reported that the opening gap at the tibial tubercle should be approximately one half of the gap at the posteromedial tibia to maintain a normal tibial slope and that a gap error of 1mm could result in a change of posterior slope of approximately 2 degrees. An increase in slope facilitates the anterior translation and subluxation of the tibia in the PCL deficient knee and can strain and damage the anterior cruciate ligament [30]. It can influence knee kinematics, stability and joint contact pressure [31].

The role of axial plane alignment after HTO is poorly understood but some authors suggest that excessive axial realignment should also be avoided [32]. Other problems with conventional HTO are that poorly performed osteotomies and incorrect orientation of the chisel or saw blade can lead to intraoperative tibial plateau fractures and injury to neurovascular structures.

It is thought that many of the difficulties outlined above can be overcome by intraoperative computer-assisted surgery or navigation procedures. Such technology has been used in other areas of orthopaedic surgery successfully, for example, total knee replacement [33, 34]. It can allow precise evaluations of deformity and intraoperative real time control of the axes obtained by correction. It can address inadvertent technical errors in conventional surgery and improve reproducibility, allowing comparison of results. Such technology can also compensate for variations in surgeon’s experiences with regard to preoperative planning. In recent years, computer navigation has been introduced to assess leg alignment intraoperatively in HTO and several groups have reported their results.

Early Work

Early attempts to improve the accuracy of HTO involved the development of preoperative planning and simulation systems which provided the surgeon with a simulation of the operation and prediction of postoperative alignment or loading [35]. Many of these systems involved two dimensional (2D) models and there were problems executing a 2D plan in 3D space [36]. A Computer Tomograph (CT)-based 3D pre-surgical planner and intraoperative guidance system was then developed which aimed to increase the accuracy and reproducibility of removing a wedge for closed wedge osteotomy [37]. However this method involved an extra procedure for the insertion of radio-opaque markers into the tibia under local anaesthesia and therefore an increased risk of infection. Furthermore, after insertion of markers, a preoperative CT scan was undertaken, leading to increased radiation exposure.

Current Computer Navigation Systems

Modern day CT-free computer navigation consists of infrared camera and tracker systems. Kinematic movements and percutaneous digitisations are used to register anatomical landmarks, avoiding the use of CT. 3D graphic models of the patient’s anatomy are created which are then linked to the surgery through the use of an intraoperative computer workstation. Several companies offer software to assist in HTO and these use slightly different methods to acquire the position and alignment of the limb. Orthopilot™ (B Braun Aesculap, Tuttlingen, Germany), VectorVision™ (Brainlab Inc, Heimsetten, Germany) and SurgiGATE™ fluoroscopy based navigation module (Medivision, Oberdorf, Switzerland) systems have been mentioned in the literature. They can be used for both medial opening wedge and closed wedge HTO. Orthopilot™ has been cited the most and the salient features are described below. It is very similar to the Vectorvision system in that both tend to rely on preoperative radiographs to determine the amount of axis correction desirable. The SurgiGATE™ system is a little different as it uses a fluoroscopic C-arm for intraoperative deformity measurement, planning and correction under navigational guidance [38].

Orthopilot ™

This navigation system has been used mostly with medial opening wedge HTO [39]. Using this technique, an infrared camera is set up and the patient positioned. Stab wounds are made on the distal femur and tibial shaft and navigation trackers are fixed by bicortical screws. A third navigation tracker is wrapped around the foot. With the newer 3D version, an additional transmitter can be fastened to the proximal third of the tibia with a 2.5mm Kirschner wire to monitor the tibial slope (3D HTO navigation).

By moving the hip, knee and ankle through the range of motion for each joint, the centres of the joints are determined. Anatomical landmarks such as the femoral epicondyles and ankle malleoli are registered percutaneously with a pointer. This provides an assessment of varus deformity and the point of intersection of the mechanical axis on the tibial plateau. The amount of knee flexion and extension are also measured. The ostoeotomy is then performed in a standard incomplete open wedge manner. Valgisation by the stepwise insertion of chisels or osteotomes is performed. These are then replaced by metal spacers. The mechanical axis is visualised continuously by the navigation system. When the required correction has been achieved, the osteotomy can be stabilised with a fixation device and the spacers replaced by graft wedges. One advantage of the system is that it does not need intraoperative fluoroscopy. A disadvantage is the inability of the older version (standard version) to control sagittal plane correction or the posterior slope of the tibia [40]. There are also concerns that the kinematic pivoting algorithm for digitising the hip centre as the rotational centre of the femur around the pelvis may not work in certain situations for example if the patient has reduced range of hip movement or is obese due for example to the limited range of motion or patient obesity. Similarly, percutaneous registration of the ankle centre may not be accurate if the patient is too obese to palpate the malleoli or if there are ankle deformities. Furthermore, the system relies on preoperative imaging through full-length radiographs which can be error prone.


An optoelectronic infrared tracking localiser is mounted on a movable stand and tracks the position of optical targets equipped with infrared light-emitting diodes (LEDs). These targets are attached to anatomical bodies and the image intensifier of the C-arm as well as other relevant surgical instruments. The workstation communicates with the infrared tracking system. No preoperative planning is necessary. The following steps are undertaken:

  1. Fixation of dynamic reference bases (DRBs) at the femur and tibia using kirschner wires and acquisition of fluoroscopic images with the calibrated fluoroscopic C-arm.
  2. Digitisation of anatomical landmarks and measurement of functional parameters.
  3. Intraoperative planning of the osteotomy plane with the aid of fluoroscopic images.
  4. Navigational guidance of bone cutting and deformity correction.

The main advantages of this system are that preoperative full-length radiographs are not required. It allows continuous visualisation of the frontal, sagittal and transverse axes. It is thought that the use of fluoroscopic images is more accurate for registering the hip centre than the pivoting algorithm.

Cadaveric Studies

In cadaveric studies, computer navigation has been shown to improve accuracy. Hankemeier et al. [41] randomly assigned twenty cadaveric legs to conventional analysis of mechanical axis using the cable method or to navigated analysis with a fluoroscopy based system. CT was performed. Compared to CT analysis of the mechanical axis, navigated intraoperative evaluation was more accurate than conventional evaluation. In another paper [42], this group also demonstrated that after performing navigated or conventional HTO randomly on these cadavers, the navigated cadavers had better mechanical axis alignmnent with lower variability and reduced radiation exposure time although the operation took longer. Lützner et al. [43] also randomly assigned 19 cadaveric legs to navigated (Orthopilot™) or conventional open-wedge HTO and found that the mean deviation of the weight-bearing line from the desired 80 percent was 1 percent in the navigated and 8.6% in the conventional operated legs. 80% of the tibial plateau width was chosen as the desired weight-bearing line in this study as there was no varus malalignment in the cadaveric legs.

These studies although encouraging, only investigated accuracy and variability in the frontal plane. Goleski et al. [44] performed navigated HTO (VectorVision™) on thirteen cadaver legs and initial coronal, sagittal and axial alignment was measured on 6 legs, 3 times each at intervals. The navigation system was not good at tracking changes in tibial torsion and had poor intra and interobserver reliability in rotational alignment. Furthermore, looking at the change in tibial slope, there were sizeable differences in the navigation and CT values and only fair inter and intraobserver reliability. Despite being able to monitor simultaneous coronal, sagittal and axial alignment with navigation, it appeared that there were limits in the accuracy of determination of the sagittal and axial plane alignment.

Conversely, Yamamoto et al. [45] undertook navigated opening wedge HTO on six human cadaver knees connected with a skeleton model and examined the preoperative and postoperative CT. The study involved the use of Orthopilot™ 3D open wedge HTO software which allows for improved intraoperative monitoring of the tibial slope and involves an additional transmitter which is fixed to the proximal tibia. The authors reported good postoperative coronal realignment as well as an insignificant change in the anatomic tibial slope but did not comment on axial plane alignment.

Purpose of the Review

To date, the results of small clinical studies have been published reporting the early experiences with navigation systems. However, there are no publications which summarise this information succinctly. The purpose of this study is to detail all the available information regarding the advances in computer-assisted high tibial osteotomy by identifying and evaluating the published literature. Through this systematic review, current pitfalls will also be discussed to direct future research.


Studies referencing the use of navigation in High Tibial Osteotomy were searched using electronic databases Medline, PubMed, ZETOC, OvidSP and Cochrane library (Wiley). To identify the relevant articles, the following keywords were used; Navigated high tibial osteotomy, Computer-assisted High Tibial Osteotomy, Navigation high tibial osteotomy, Orthopilot, Surgigate, Medivision. No date limits were set. The abstracts of all hits were reviewed. Studies met the inclusion criteria if they 1) involved patients with medial unicompatmental gonarthrosis with varus deformity undergoing navigated HTO 2) were written in English 3) commented on the postoperative change in mechanical or anatomical alignment. Case reports and expert opinions were excluded and duplicates were sifted out. Suitable papers were examined and their references were also hand screened for relevant citations. A total of 47 papers were reviewed. Ten articles were identified as relevant according to the inclusion criteria.

Study characteristics such as year of publication, type of study, mean age, surgical technique, follow-up duration and outcomes were extracted by one reviewer. An electronic database was created. Outcomes of interest included correction of mechanical axis, operation duration, change of posterior tibial slope and complications associated with navigation.


The clinical results of navigated HTO are outlined in Table 1.

Table 1.

Clinical Studies Examining the Outcomes of Navigation in High Tibial Osteotomy

Study Group Type of Study No of Patients Follow-Up Navigation System Internal Fixation Findings Complications Related to Navigation
Wang 2005 [38] Case series at two centres; navigated open, closed and dome osteotomy 31 12 weeks Surgigate Not stated 26 patients treated successfully with good correction of coronal alignment 5 technical problems leading to conversion to conventional technique
Saragaglia & Roberts 2005 [47] Comparative study comparing navigated and conventional OWHTO 56 (28 in each group) Post operative Orthopilot AO T-plate Navigated group – better correction of mechanical axis; better reproducibility No mention
Baur & Schuh 2006 [46] Case series navigated OWHTO 54 Post operative Orthopilot Not stated Good correction of mechanical axis; good reproducibility Haematoma of distal pin track
Maurer &Wassmer 2006 [6] Comparative study – navigated v conventional OWHTO 67 (23 navigated, 44 conventional) Post operative Orthopilot Synthes Tomofix Navigated group – better correction of mechanical axis, better reproducibility. Operation time 10 mins longer in navigated group None
Song 2007 [48] Case series navigated OWHTO 40 3 months Orthopilot B Braun Aesculap open wedge plate Good correction of mechanical axis, posterior tibial slope maintained None
Kim 2009 [40] Comparative study – navigated v conventional OWHTO 85 (90 knees; 43 conventional, 47 navigated) 1 year Orthopilot Taesan Sol Puddu or Aesculap dual open wedge plate Navigated group - better correction of mechanical axis and weightbearing line, better functional scores. No difference in tibial slope in either group. No difference in operative time between groups. 2 cases of delayed union, one varus collapse, all associated with breakage of lateral tibial cortex during medial opening
Bae 2009 [52] Comparative study navigated v conventional CWHTO 82 (100 knees; 50 conventional, 50 navigated Post operative Vectorvision Miniplate staple Navigated group – better correction of mechanical axis and better control of tibial slope. None mentioned
Iorio 2010 [49] Case series navigated OWHTO 13 (14 knees; 3D HTO navigation in 6 patients) 5-35 months (mean 12.6) Orthopilot B Braun Position HTO plate Good correction of mechanical axis. No change in Insall-Salvati index postoperatively. Good functional scores postoperatively. Good control of tibial slope with 3D navigation only. Mean operative time 78.9 mins None
Akamatsu 2011 [50] Comparative study of navigated v conventional OWHTO 48 (59 knees) 1 year Orthopilot Synthes Tomofix Navigated group – less undercorrection of femorotibial angle and Tibial slope preserved better. No difference in functional scores between groups. Navigated operations took 16 mins longer None
Gebhard 2011 [51] Multicentre case series of navigated OWHTO 51 6 weeks Vectorvision Tomofix 7 patients with postoperative mechanical axis out of range. Mean length surgery 105 mins 8 intraoperative technical complications

Early studies using Orthopilot™ [46] in 55 patients undergoing HTO showed good correlation between navigated measurements and those obtained from pre and postoperative radiographs. Good corrections of coronal alignment were achievable consistently with only one complication of haematoma of the distal pin track.

Also using Orthopilot™, Saragaglia and Roberts [47] compared 28 navigated open wedge HTOs with 28 conventional HTOs. The results demonstrated a 96% reproducibility in achieving a mechanical axis of 184º ± 2º in the navigated group compared to a 71% reproducibility in achieving a mechanical axis of 184º ± 2º in the conventional osteotomy group (p<0.0015). The authors stressed that the conventional group had received stringent preoperative and perioperative planning and attention to detail. One flaw of the study was that the conventional HTOs were performed at an earlier timeframe to the navigated HTO.

Maurer and Wassmer [6] looked at 67 open wedge HTOs performed between 2003 and 2006, the first 23 of which were performed by conventional technique and the next 44 of which were performed with the Orthopilot system™. There was good correlation in the navigated group between preoperative planning and preoperative computer navigation regarding the angle of varus deformity. There was also good correlation between the navigated correction angle and postoperative measurements in another full-leg view. Navigation resulted in a statistically higher accuracy of the postoperative mechanical leg axis within a range of 3° to 5° valgus and fewer outliers. It extended the total operative time by only ten minutes.

A retrospective comparative study by Kim et al. [40] looked at the one year follow-up after 47 navigated and 43 conventional open wedge HTO. Similar to previous studies, the navigated group showed better results than the conventional group in both the mechanical axis and the coordinate of the weightbearing line on postoperative radiographs with better reproducibility. There was no significant difference in the complication rate in either group. Although the version of Orthopilot™ used by these authors was unable to control sagittal plane correction or posterior tibial slope, the authors took additional measures to control for this. They inserted two guide pins to overlap each other on a 10° caudally tilted fluoroscope to simulate the tibial plateau view in both groups. This enabled the osteotomy to parallel the inherent slope of the tibia in the sagittal plane. Also, when adjusting the opening wedge, the authors ensured that the opening at the posteromedial corner of the tibia was about two times that at the anteromedial corner. Furthermore, in the navigated group, two different sized plates were used, the anterior plate being approximately 2mm smaller than the posterior plate and in the conventional group two wedge-shaped grafts, different in height were placed into the osteotomy site to replicate the slope. There was no difference in either group between the pre or postoperative posterior slope (approx 10°). There was also no difference in the total operative time, although this was partly because autogenous bone grafts were used in the conventional group and allografts in the navigated group. The navigation group showed better results in both the mean Hospital for Special Surgery knee score and the mean Lysholm knee score. Limitations of this study included the short follow-up and the fact that different plates were used in each of the groups which may have influenced results based on their individual biomechanical properties.

Song et al. [48] performed 40 navigation-assisted open wedge HTO and followed patients up with radiographs 3 months postoperatively. They also reported good correction of mechanical axis with few outliers. Like Kim et al. they took precautions to maintain the tibial slope, for example by placing the posterior plate as posteriorly as possible and by using an anterior plate that was shorter. This group maintained the anterior gap (at the posteromedial aspect of the tibial tuberosity) at 70% of the posterior opening gap and found that the posterior slope was well maintained. There were no complications related to navigation in this study.

Iorio et al. [49] prospectively followed-up 13 patients who underwent 14 navigated open wedge HTO after a mean of 12.6 months. Like the cadaveric study performed by Yamamoto et al. [45], the authors used Orthopilot™ 3D open wedge HTO software, although only 6 patients had the additional transmitter fixed to monitor the tibial slope. Good correction of femorotibial mechanical axis was achieved overall and coronal and sagittal plane angles detected through navigation correlated well with radiograph measurements. In the six patients in whom the posterior tibial slope was evaluated, there was an insignificant change between the preoperative and postoperative values. Conversely, in patients in whom the slope was not evaluated, there was a mean increase of the slope of 2.8° ± 3.3° seen on comparing pre and postoperative radiographs. In all patients, the HTO had no significant effect on the patella height (Insall-Salvati index) and pain and functional scores improved significantly postoperatively (Visual Analogue Score, Modified Cincinnati and Knee Society Score). There were no complications and the mean operating time was 78.9 minutes. Again this study was limited by a small number of patients, short and variable follow-up and the lack of a control group. Akamatsu et al. [50] compared the results from 28 conventional HTO and 31 navigated HTO using the standard version of Orthopilot™. In this study, the mean postoperative femorotibial angle was higher in the conventional group, i.e. navigation reduced the risk of undercorrection in the coronal plane. By maintaining the postoperative full extension to the same degree as preoperative full extension using the navigation system, the authors found they could control the posterior tibial slope. Mean changes in posterior tibial slope before and after opening wedge HTO were 3.5° in the conventional group and 0.6° in the navigated group (p<0.001). Operations in the navigated group took on average 16 minutes longer than in the conventional group and there were no differences in functional scores or complications between the groups.

Successful outcomes have also been published using the Brainlab system for navigation. Gebhard et al. [51] undertook a prospective multicentre study case series at six centres to look at 6 week outcomes in 51 patients after open wedge HTO. The mean length of surgery was 105 minutes. 85% of patients achieved desirable mechanical axis deviations. However eight intraoperative complications occurred which were all associated with the navigation system being used during the learning phase of the study. This again highlights the steep learning curve and that experience in using the technology is fundamental in achieving good results.

Very few studies have looked at navigation using the closed wedge technique. Bae et al. [52] undertook 50 closed wedge HTO procedures using the VectorVision system and compared the results with 50 conventional closed-wedge HTO procedures undertaken during the preceding 12 years. As before, there was a positive correlation between the measurement data obtained with the navigation system and that with the radiological measurement and good inter and intraobserver reliability. The coronal correction angles were more accurate in the navigated group and the variability of correction was lower. There was also less decrease in the posterior slope angle postoperatively in the navigated group which the authors attributed to accurate orientation of the wedge and proper placement of the hinge axis under guidance. The main limitation of this study was that a prospective cohort was compared with a retrospective cohort of patients, some of whom had their operation several years beforehand. There was also some discrepancy between the demographics of the two groups.

Wang et al. [38] have experience using the Surgigate system. As this system does not rely on preoperative planning based on full leg radiograph images, which they describe as a ‘manual cutting and tracing paper process’, they state that it is less likely to result in under or overestimation of the correctional angle. The fluoroscopic C-arm provides an intraoperative tool for deformity measurement, interactive planning and precise performance of deformity correction all at the time of surgery. This group looked at 31 patients who underwent navigated HTO at two centres. Five patients were converted to conventional HTO as there were technical problems with the navigation system. The remaining patients underwent successful correction of coronal plane deformity without complication. The extra operative time ranged from 10 to 30 minutes. The authors did not comment on whether they found any changes in sagittal or axial plane.


In this systematic review, we have looked at the clinical outcomes of using navigation systems for HTO. The studies we examined have demonstrated that the use of navigation holds some disadvantages such as the long learning curve. Technical pitfalls can occur, such as line of sight issues, registration failures and mechanical or software malfunctions [53]. Surgeons must be comfortable with the conventional osteotomy method in case such problems with the navigation system occur intraoperatively. In addition, current navigation techniques measure the mechanical axis without application of weight bearing conditions which can later account for over or undercorrections. Another disadvantage is that the additional time required for navigation ranges from 10 to 30 minutes potentially increasing the anaesthetic risk. The use of navigation entails stab wounds to the tibia and femur for fixing the trackers which can also inherently increase the risk of infection or fracture [54, 55] and a case of heterotopic ossification has also been described [56]. Navigation also incurs extra costs compared to the conventional technique.

Advantages of computer-assisted high tibial osteotomy are that it can substantially improve the accuracy as has been consistently seen from cadaveric and clinical studies. This can improve postoperative outcomes and decrease the radiation time. It can also provide real time intraoperative information about coronal, sagittal and transverse axes which can compensate for the shortcomings of preoperative radiograph planning. To obtain the very best results, the registration process must be precise and efforts should be taken to obtain accurate data. It is important to check for changes of the leg axis during preoperative varus and valgus stress as a leg axis discrepancy may exist between weight-bearing full leg radiography and non weight-bearing navigated preoperative data. This also enables medial and lateral soft tissue status to be differentiated. Postoperative varus-valgus stress testing and observations of any axis changes during heel pushing can predict postoperative fixation stability, collateral ligament status and leg axis during full weightbearing [10].

Results concerning tibial slope control have been conflicting. Regarding Orthopilot, many of the studies above were carried out before the updated Orthopilot module was released. This does allow for tibial slope control but has been described by some as being cumbersome [10]. Regarding open wedge HTO, Song et al. have recommended the following to avoid unintended increases in the posterior slope:

  1. The osteotomy should be parallel to the joint line in the sagittal plane (normal posterior slope).
  2. The posterior corticotomy should be complete and posteromedial soft tissue should be released.
  3. The plate should be placed as posterior as possible.
  4. The postoperative full extension should be kept to the same degree as the preoperative full extension using the navigation system.
  5. The anterior opening gap at the anteromedial cortex of the proximal tibia behind the tuberosity should be approximately 67% of the posterior opening gap at the most posteromedial corner of the proximal tibia [48]. Alternatively, the opening gap at the tibial tubercle should be one-half that of the opening gap at the posteromedial tibia [29].


Further research should be directed towards developing more accurate navigation tools which can monitor sagittal and axial plane alignment reliably and therefore correct multiplanar deformity. In the future, it is possible that better quantitative alignment tracking may allow osteotomy to be used successfully for patients with osteoarthritis and ligament instability. With this in mind, biomechanical studies are required to define ideal alignments in the coronal and sagittal planes for individualised cartilage, meniscus and ligament stability conditions. Longer follow-up studies will also be interesting to compare the long-term follow-up of navigated versus conventional HTO.


None declared.


Neither of the authors have a conflict of interest to declare in relation to the production of this manuscript.


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