RESEARCH ARTICLE


Percutaneous Implantation of Autologous Bone Marrow Osteoprogenitor Cells as Treatment of Bone Avascular Necrosis Related to Sickle Cell Disease



Philippe Hernigou*, 1, Gilsasio Daltro2, Paolo Filippini1, Martin Mukisi Mukasa3, Olivier Manicom3
1 Department of Orthopaedic Surgery, 51 Avenue du Maréchal de Lattre de Tassigny, 94010 cedex Créteil, France
2 Hospital Edgar Santos, University Federal of Bahia, Salvador, Brazil
3 Hôpital de Point à Pitre – Guadeloupe, France


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Creative Commons License
© Hernigou et al.; Licensee Bentham Open.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/license/by/2.5/), which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited.

* Address correspondence to this author at the Service de Chirurgie Orthopédique et Traumatologique, Hospital Henri Mondor, 51 avenue du Maréchal de Lattre de Tassigny, 94010 cedex Créteil, France; Tel: 00 33 1 49 81 26 01; Fax: 00 33 1 49 81 26 08; E-mail: philippe.hernigou@wanadoo.fr


Abstract

The treatment of bone a vascular necrosis is a big challenge considering the youthfulness of the patients involved by necrosis in sickle cell disease and the importance of the generated disability. A vascular osteonecrosis is an epiphysis pathology which could be treated by joint replacement with success, however, multiple surgical procedures are mostly necessary during the patient’s life with a hazardous long term functional results. The treatment by autologous bone marrow grafting is an effective alternative which preserve the native joint. Using this mini-invasive high technology surgical treatment in early stages, a joint replacement could be avoided in many patients.

Keywords: Avascular osteonecrosis, marrow grafting, mesenchymal stem cell, bone regeneration.