Relief of Lower Back and Leg Pain after Myelography

Rui Guo1, 2, Toshihiko Sakakibara2, Tetsutaro Mizuno2, Koji Akeda3, Tetsushi Kondo4, Yuichi Kasai2, *
1 School of Medicine, Jiangsu University, Zhenjiang, China
2 Department of Spinal Surgery and Medical Engineering, Mie University Graduate School of Medicine, Tsu City, Mie, Japan
3 Department of Orthopaedic Surgery, Mie University Graduate School of Medicine, Tsu City, Mie, Japan
4 Department of Orthopaedc Surgery, Murase Hospital, Mie, Japan

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© Guo et al.; Licensee Bentham Open

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution-Non-Commercial 4.0 International Public License (CC BY-NC 4.0) (, which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the Department of Spinal Surgery and Medical Engineering, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu city, Mie 514-8507, Japan; Tel: +81-59-231-6024; Fax: +81-59-231-6032; E-mail:



It is well-known that many patients will have adverse reactions such as headache and nausea after undergoing myelography, but we have often seen cases where symptoms such as lower back pain and leg pain were alleviated following myelography. To the best of our knowledge, such clinical cases of post-myelographic alleviation have not been reported.

Materials and Methods:

A total of 325 patients with a degenerative lumbar spinal disorder who underwent myelography were prospectively investigated at four hospitals from April 2012 to March 2014 to survey the post-myelographic alleviation of lower back and leg pain prospectively. The severities of lower back pain, leg pain and numbness of the lower extremities were evaluated and intermittent claudication distance was measured before myelography. The magnetic resonance imaging (MRI) findings and myelographic findings were also evaluated for the patients that their symptoms were improved.


Thirty-five of 325 cases (10.8%) of these patients had their symptoms alleviated after undergoing myelography; 26 cases of lower back pain, two cases of leg pain, two cases of numbness of the lower extremity, and five cases of intermittent claudication.


In the patients of a degenerative lumbar spinal disorder, about 10% cases with lower back pain or intermittent claudication had post-myelographic alleviation. Intradural injection therapy might be a therapeutic method to alleviate these symptoms.

Keywords: Intradural injection therapy, Leg pain, Lumbar spinal disorders, Lower back pain, Myelography.