Sheep Hip Arthroplasty Model of Failed Implant Osseointegration

Thomas Jakobsen*, 1, Søren Kold2, Jørgen Baas1, Kjeld Søballe1, Ole Rahbek1
1 Orthopaedic Research Laboratory, Department of Orthopaedics, Aarhus University Hospital, Aarhus, Denmark
2 Aalborg University Hospital, Department of Orthopaedics, Aalborg, Denmark

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© Jakobsen et al.; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the Orthopaedic Research Laboratory, Aarhus University Hospital, Norrebrogade 44, Building 1A, DK-8000 Aarhus C, Denmark; Tel: +45 8949 4134; Fax: +45 8949 4150; E-mail:


Early secure stability of an implant is important for long-term survival. We examined whether micromotion of implants consistently would induce bone resorption and formation of a fibrous membrane and thereby prevent osseointegration.

One micromotion implant was inserted into one of the medial femoral condyles in ten sheep. The micromotion device consists of an anchor bearing a PMMA implant and a PE plug. During each gait cycle the PE plug will make the PMMA implant axially piston 0.5 mm. After 12 weeks of observation the bone specimens were harvested and a post-mortem control implant was inserted into the contra-lateral medial femoral condyle.

Histomorphometrical evaluation showed that the surface on the implant observed for 12 weeks was covered by fibrous tissue. The control implants were covered by lamellar bone. No difference was found with respect to the volume fraction of lamellar bone in a 1 mm zone around the implants.

This study indicates that implant micromotion is sufficient to induce bone resorption and formation of a fibrous membrane.

Keywords:: Bone resorption, implant fixation, implant micromotion.