RESEARCH ARTICLE


Multiple Infectious Complications in a Severely Injured Patient with Single Nucleotide Polymorphisms in Important Innate Immune Response Genes



Maarten W.G.A. Bronkhorst1, Peter Patka2, Esther M.M. Van Lieshout*, 1
1 Trauma Research Unit Department of Surgery, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
2 Department of Accident & Emergency, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands


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© Bronkhorst et al.; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the Erasmus MC, University Medical Center Rotterdam, Trauma Research Unit, Department of Surgery, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands; Tel: +31.10.7031050; Fax: +31.10.70.32396; E-mail: e.vanlieshout@erasmusmc.nl


Abstract

Trauma is a major public health problem worldwide. Infectious complications, sepsis, and multiple organ dysfunction syndrome (MODS) remain important causes for morbidity and mortality in patients who survive the initial trauma. There is increasing evidence for the role of genetic variation in the innate immune system on infectious complications in severe trauma patients. We describe a trauma patient with multiple infectious complications caused by multiple micro-organisms leading to prolonged hospital stay with numerous treatments. This patient had multiple single nucleotide polymorphisms (SNPs) in the MBL2, MASP2, FCN2 and TLR2 genes, most likely contributing to increased susceptibility and severity of infectious disease.

Keywords: Complications, genetic variation, infection, multiple organ dysfunction syndrome, single nucleotide polymorphism, systemic inflammatory response syndrome, trauma.