Peripheral Nerve Injury: Principles for Repair and Regeneration
Griffin M.F1, Malahias M1, Hindocha S*, 2, Wasim S Khan 3
Identifiers and Pagination:Year: 2014
Issue: Suppl 1
First Page: 199
Last Page: 203
Publisher Id: TOORTHJ-8-199
Article History:Received Date: 2/11/2013
Revision Received Date: 1/2/2014
Acceptance Date: 2/4/2014
Electronic publication date: 27 /6/2014
Collection year: 2014
open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/) which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited.
Peripheral Nerve Injuries are one of the most common causes of hand dysfunction caused by upper limb trauma but still current management has remained suboptimal. This review aims to explain the traditional view of pathophysiology of nerve repair and also describe why surgical management is still inadequate in using the new biological research that has documented the changes that occur after the nerve injury, which, could cause suboptimal clinical outcomes. Subsequently presentation and diagnosis will be described for peripheral nerve injuries. When traditional surgical repair using end-to-end anastomosis is not adequate nerve conduits are required with the gold standard being the autologous nerve. Due to associated donor site morbidity and poor functional outcome documented with autologous nerve repair several new advancements for alternatives to bridge the gap are being investigated. We will summarise the new and future advancements of non-biological and biological replacements as well as gene therapy, which are being considered as the alternatives for peripheral nerve repair.