Advances and Developments in the Use of Human Mesenchymal Stem Cells – A Few Considerations

Lucinda Kennard1, Gopiga Thanabalasundaram2, Hiteshkumar D Tailor*, 2, Wasim S Khan3
1 Foundation Training Department, East of England NHS Deanery, Cambridge, CB21 5XE, UK
2 University College London Medical School, Gower Street, London WC1E 6BT, UK
3 University College London Institute of Orthopaedics and Musculoskeletal Sciences, Royal National Orthopaedic Hospital, Stanmore, Middlesex, HA7 4LP, UK

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© Kennard et al.; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the University College London Medical School, Gower Street, London WC1E 6BT, UK; Tel: +44 20 7679 0858; Fax: 020 7679 0890; E-mails:,


One less visited area in musculoskeletal stem cell research is the effects of donor age on quality of stem cells. The prevalence of degenerative orthopaedic conditions is large, and the older population is likely to receive great benefit from stem cell therapies. There are many known growth factors involved in controlling and influencing stem cell growth which are also related to cell senescence. Of which, expressions are found to be altered in mesenchymal stem cells from older donors. Considerations must also be taken of these mechanisms which also have a role in cell cycle and tumour suppression.

Keywords: Ageing, bone marrow, donor, growth factors, mesenchymal stem cells, senescence.