Advances and Developments in the Use of Human Mesenchymal Stem Cells – A Few Considerations
Lucinda Kennard1, Gopiga Thanabalasundaram2, Hiteshkumar D Tailor*, 2, Wasim S Khan3
Identifiers and Pagination:Year: 2011
Issue: Suppl 2
First Page: 249
Last Page: 252
Publisher ID: TOORTHJ-5-249
Article History:Received Date: 30/1/2011
Revision Received Date: 14/3/2011
Acceptance Date: 6/4/2011
Electronic publication date: 28/7/2011
Collection year: 2011
open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
One less visited area in musculoskeletal stem cell research is the effects of donor age on quality of stem cells. The prevalence of degenerative orthopaedic conditions is large, and the older population is likely to receive great benefit from stem cell therapies. There are many known growth factors involved in controlling and influencing stem cell growth which are also related to cell senescence. Of which, expressions are found to be altered in mesenchymal stem cells from older donors. Considerations must also be taken of these mechanisms which also have a role in cell cycle and tumour suppression.