RESEARCH ARTICLE


Significance of LRP and PPAR-γ Expression in Lipomatous Soft Tissue Tumors



Takashi Tajima1, Takeshi Morii*, 1, Fumihito Kikuchi2, Akihiko Matsumine3, Hiroaki Murata4, Hiroo Nobuto5, Kazuo Mochizuki1
1 Department of Orthopaedic Surgery, Kyorin University School of Medicine, Tokyo, Japan
2 Department of Pathology, Hitachi General Hospital, Ibaraki, Japan
3 Department of Orthopaedic Surgery, Mie University Graduate School of Medicine, Mie, Japan
4 Department of Orthopaedic Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan
5 Department of Orthopaedic Surgery, Hiroshima Prefectural Hospital, Hiroshima, Japan


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Creative Commons License
© Tajima et al.; Licensee Bentham Open.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/) which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited.

* Address correspondence to this author at the Department of Orthopaedic Surgery, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo, 181-8611, Japan; Tel: +81-422-47-5511; Fax: +81-422-48-4206; E-mail: t-morii@gb3.so-net.ne.jp


Abstract

Background:

Molecular mechanism of differentiation in lipogenic tumor is still unknown in detail. Low-density lipoprotein receptor-related protein (LRP) and peroxisome proliferator-activated receptor gamma (PPAR-γ), representative regulatory molecules of lipogenic differentiation, have been reported today as multi-functional molecules and to modulate tumorigenesis in various kind of cancer. To date, diagnostic and therapeutic significance of the expression of these molecules in lipogenic tumors are not defined.

Methods:

The immunohistochemical expression status of LRP and PPAR-γ in various grades of 54 lipogenic tumors was analyzed. Correlation between the expression levels and the differentiation of the tumors was confirmed. For statistical analyses, the Kruskal-Wallis test, the Steel-Dwass test and the Mann–Whitney U test were used.

Results:

LRP and PPAR-γ expression was detected in 50 (92.6%) and 44 (81.5%) cases, respectively. The expression level in LRP was significantly higher in cases with well differentiated liposarcoma, pleomorphic liposarcoma and dedifferentiated liposarcoma than in lipoma. Compared with lipoma or well differentiated liposarcoma, significant elevation in expression level of PPAR-γ was confirmed in myxoid liposarcoma, pleomorphic liposarcoma, dedifferentiated liposarcoma and the differentiated area of dedifferentiated liposarcoma.

Conclusion:

The up-regulation of LRP and PPAR-γ in higher grade cases, i.e. less differentiated tumors than in low grade cases was shown, suggesting the candidate role of these molecules as tumor progression modulators rather than regulatory molecules of differentiation in lipogenic tumors.

Keywords:: Lipogenic tumor, LRP, PPAR-γ, immunohistochemistry..