Biofilm and the Role of Antibiotics in the Treatment of Periprosthetic Hip and Knee Joint Infections

Yusuf H. Mirza1, *, Rosamond Tansey1, Mohamed Sukeik2, Mohammed Shaath3, Fares Sami Haddad1
1 Department of Trauma and Orthopaedics, University College London Hospital, 235 Euston Road, NW1 2BU, London, United Kingdom
2 Department of Trauma and Orthopaedics, Royal London Hospital, Whitechapel, London, E1 1BB, United Kingdom
3 Department of Trauma and Orthopaedics, North Manchester General Hospital, Delaunay’s Road, Crumpsall, M8 5RB, United Kingdom

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© Mirza et al.; Licensee Bentham Open

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution-Non-Commercial 4.0 International Public License (CC BY-NC 4.0) (, which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the Department of Trauma and Orthopaedics, University College Hospital London, 235 Euston Road, NW1 2BU, London, United Kingdom; Tel: 0044 (0) 7530271137; E-mail:


An increasing demand for lower limb arthroplasty will lead to a proportionate increase in the need for revision surgery. A notable proportion of revision surgery is secondary to periprosthetic joint infections (PJI). Diagnosing and eradicating PJI can form a very difficult challenge. An important cause of PJI is the formation of a bacterial biofilm on the implant surface. Our review article seeks to describe biofilms; their definitions and formation, common causative bacteria, prophylactic and therapeutic antibiotic therapy.

Keywords: Antibiotics, Biofilm, Periprosthetic joint infection, Total hip arthroplasty, Total knee arthroplasty.