Results of Particulated Juvenile Articular Cartilage Allograft Transplantation in the Knee in Five Years



Diana C. Patterson1, *, James D. Dieterich1, Meredith Bartelstein1, Sheena Ranade1, Darren Fitzpatrick2, Johnathan Glashow1, Alexis C. Colvin1, James N. Gladstone1
1 Department of Orthopaedics, Mount Sinai Health System, New York, NY, USA
2 Department of Radiology, Mount Sinai Health System, New York, NY, 10128, USA

Abstract

Objective:

Current options full-thickness chondral lesions of the knee in young, active patients are limited in their ability to stimulate new cartilage growth. Juvenile particulated articular cartilage allograft has good short-term outcomes. Our hypothesis is that DeNovo NT transplantation in the knee would continue to demonstrate good clinical and radiographic outcomes in almost five years postoperatively.

Design:

Demographics and operative reports of all patients who underwent DeNovo cartilage transplant in the knee from 2010-2015 were collected. Clinical outcomes were evaluated with the modified Lysholm Knee score. MRIs at a minimum of 6 months postoperatively were assigned a Magnetic Resonance Observation of Cartilage Repair Tissue (MOCART) score.

Results:

20 patients (22 knees) underwent DeNovo cartilage transfer to 27 lesions. Average cross-sectional area was 3.00cm2. MRI at a mean of 11.7 months showed 14(74%) with complete fill, 1(5%) with hypertrophy, 4(21%) with incomplete or exposed subchondral bone. Clinical follow up at a mean of 4.2 years showed improvement in the Lysholm from 45.28 ±21.5 to 79.17 ± 20.13 (p<0.001).

Conclusion:

In this longest published follow up published of DeNovo transfer in the knee, we demonstrate that this cartilage implant can have sustained good clinical and radiographic outcomes at mid-term follow-up.

Keywords: Chondral defect, DeNovo NT, Juvenile cartilage allograft, Articular cartilage lesion.


Abstract Information


Identifiers and Pagination:

Year: 2019
Volume: 13
Publisher Item Identifier: EA-TOORTHJ-2019-11

Article History:

Received Date: 25/02/2019
Revision Received Date: 04/09/2019
Acceptance Date: 19/09/2019
Electronic publication date: 25/10/2019
Collection year: 2019

© 2019 Patterson et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


* Address correspondence to this author at the Department of Orthopaedic Surgery 5 E 98th St, 9th Fl, Box 1188 New York NY 10029, USA; P: 212-241-1645; Tel: ??????; E-mail: diana.c.patterson@gmail.com