Results of Particulated Juvenile Articular Cartilage Allograft Transplantation in the Knee in Five Years

Diana C. Patterson1, *, James D. Dieterich1, Meredith Bartelstein1, Sheena Ranade1, Darren Fitzpatrick2, Johnathan Glashow1, Alexis C. Colvin1, James N. Gladstone1
1 Department of Orthopaedics, Mount Sinai Health System, New York, NY, USA
2 Department of Radiology, Mount Sinai Health System, New York, NY, 10128, USA



Current options full-thickness chondral lesions of the knee in young, active patients are limited in their ability to stimulate new cartilage growth. Juvenile particulated articular cartilage allograft has good short-term outcomes. Our hypothesis is that DeNovo NT transplantation in the knee would continue to demonstrate good clinical and radiographic outcomes in almost five years postoperatively.


Demographics and operative reports of all patients who underwent DeNovo cartilage transplant in the knee from 2010-2015 were collected. Clinical outcomes were evaluated with the modified Lysholm Knee score. MRIs at a minimum of 6 months postoperatively were assigned a Magnetic Resonance Observation of Cartilage Repair Tissue (MOCART) score.


20 patients (22 knees) underwent DeNovo cartilage transfer to 27 lesions. Average cross-sectional area was 3.00cm2. MRI at a mean of 11.7 months showed 14(74%) with complete fill, 1(5%) with hypertrophy, 4(21%) with incomplete or exposed subchondral bone. Clinical follow up at a mean of 4.2 years showed improvement in the Lysholm from 45.28 ±21.5 to 79.17 ± 20.13 (p<0.001).


In this longest published follow up published of DeNovo transfer in the knee, we demonstrate that this cartilage implant can have sustained good clinical and radiographic outcomes at mid-term follow-up.

Keywords: Chondral defect, DeNovo NT, Juvenile cartilage allograft, Articular cartilage lesion.

Abstract Information

Identifiers and Pagination:

Year: 2019
Volume: 13
Publisher Item Identifier: EA-TOORTHJ-2019-11

Article History:

Received Date: 25/02/2019
Revision Received Date: 04/09/2019
Acceptance Date: 19/09/2019
Electronic publication date: 25/10/2019
Collection year: 2019

© 2019 Patterson et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Department of Orthopaedic Surgery 5 E 98th St, 9th Fl, Box 1188 New York NY 10029, USA; P: 212-241-1645; Tel: ??????; E-mail: